Quercetin 3 Rutinoside Facilitates Protection Against Radiation Induced Genotoxic and Oxidative Damage A Study in C57bl 6 Mice

Radiation-induced oxidative stress and haematopoietic genomic instability is the major concern during planned or unplanned exposure. Use of natural phytochemicals an emerging strategy to prevent from harmful effects radiation. In current investigation, Quercetin 3-Rutinoside (Q-3-R), a polyphenolic bioflavonoid, has been evaluated against gamma radiation (2Gy) induced genotoxic damage imbalance in mice. Mice were administered with Q-3-R (10mg/kg body weight) 1hr prior irradiation for its antioxidant potential. Anti-genotoxic potential was assessed terms chromosomal aberrations bone marrow cells. Findings revealed that had very high reducing potential, effectively scavenged 1,1-Diphenyl-2-picryl hydrazyl (DPPH) hydrogen peroxide radicals, chelated metal ions inhibited lipid peroxidation dose dependant manner. The glutathione (GSH) levels found elevated (p<0.05), while reduced malondialdehyde (MDA) seen blood liver tissues pretreated Significant (p<0.01) reduction Reactive Oxygen Species (ROS) (dicentrics, rings, fragments, end association, robertsonian translocation) following pretreatment present findings demonstrate can minimise radiation-induced damages be explored further used as potent radioprotector humans.